Sample Instructions for Administering Oral Viscous Budesonide for Eosinophilic Esophagitis (EoE)

Budesonide has a naturally bitter taste, so it is commonly mixed with a sweetener such as sucralose (e.g., Splenda), pancake syrup, chocolate syrup, honey, or agave nectar to create a thick slurry, known as oral viscous budesonide.

Suggested Sweetener Mixtures:

  • Splenda: 5 packets

  • Applesauce: 1 teaspoon

  • Honey or Agave Nectar: 1 teaspoon

Steps to Prepare and Administer Oral Viscous Budesonide:

  1. Prepare the Budesonide Solution:

    • Open the budesonide respule by twisting off the tab on the container.

    • Pour the liquid medicine (approximately 2 mL or less than ½ teaspoon) into a small cup, such as a measuring cup or medicine cup.

  2. Mix with a Vehicle:

    • Add the chosen sweetener or vehicle (e.g., honey, syrup, or Splenda).

    • Stir the mixture until it reaches a thick, slurry-like consistency. This consistency is necessary to coat the esophagus effectively.

  3. Administer the Solution:

    • Swallow the entire mixture slowly to ensure adequate esophageal coating.

  4. Post-Dosing Instructions:

    • Avoid eating or drinking anything for at least 45 minutes after taking the medicine to maximize its effectiveness.

    • You may rinse your mouth and spit out the water or brush your teeth after swallowing the medicine, but do not swallow any water during this time.

Medical Disclaimer (Educational Use Only)
This page provides general educational information and is not medical advice. It does not replace care from your clinician and does not create a doctor–patient relationship. Medication instructions differ by individual and prescription

Follow the directions from your prescribing clinician and pharmacist. If you have questions, contact your care team. If you have trouble breathing, severe chest pain, inability to swallow, or signs of an allergic reaction, seek emergency care immediately.